At present there are no randomized studies on the effects of long-term testosterone use on breast cancer risk. All hormonal pathways included in this complex hormonal and surgical procedure of transgender surgery have important implications for women undergoing prophylactic mastectomy because of a high risk of possible breast cancer.
The case in question involves a female to male transsexual, who underwent complex sex reassignment surgery after bilateral subcutaneous nipple sparing mastectomy (weight of removed breast tissue: left breast tissue, 275 g; right breast tissue, 295 g), presented 1 year after surgery with a painless left areoral mass. Samples of the left and right breast tissues sent for pathological analysis following subcutaneous mastectomy were benign.The patient was 42 years old at the time the breast cancer was discovered, and 41 years old at the time of transgender surgery. The patient started testosterone therapy 18 months prior to sex reassignment (250 mg intramuscularly every 2 weeks). After the sex reassignment surgery,
he received 250mg testosterone every 17 days for the
next 12 months. At the time of sex change surgery, the patient was premenopausal. The patient did not have any relatives with a history of any type of cancer. Family
history of breast cancer and ovarian cancer in first-degree or second-degree relatives
was thus negative, with no prior breast biopsies in clinical history, and therefore
he was not a high-risk patient for breast cancer.
Prior to the backlash against feminism, female transition was at most rare. Fast forward to today's Trans Trending happening among females under the age of 25, thousands are transitioning yearly. The serious study of breast cancer in females who have had "top surgery" and been hormonally treated with testosterone in our mass female transition era is NIL. The lack of breast cancer studies in trans females also hurts trans females from the ability to properly utilize breast cancer advances such as mammograms.
Clearly there is breast tissue left in EVERY single "top surgery" victim, and surely every one of those victims will need to have some sort of regular mammogram. But without those studies, we are left with questions such as, at what point after hormonal use will a trans female need to have a mammogram? Will her age make a difference? Will the amount/frequency of hormone use make a difference? Will family cancer make a difference? Should certain diets be maintained to combat testosterone poisoning to the female body? And a whole host of other questions, none of which it seems has any real answers any time soon. Like most minority health issues, we wont have any answers until the bodies start piling up.